Afatinib dimaleate [850140-73-7]
HY-10261A
Overview
- SupplierMedChem Express
- Product NameAfatinib dimaleate [850140-73-7]
- Delivery Days Customer10
- CAS Number850140-73-7
- CertificationResearch Use Only
- Estimated Purity95%
- Molecular FormulaC32H33ClFN5O11
- Molecular Weight718.08
- Scientific DescriptionAfatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.
- SMILESO=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200