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Almorexant hydrochloride [913358-93-7]

Research Use Only
HY-10805A
MedChem Express
CAS Number913358-93-7
Product group Chemicals
Estimated Purity99.28%
Molecular Weight549.02
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Almorexant hydrochloride [913358-93-7]
  • Delivery Days Customer
    10
  • CAS Number
    913358-93-7
  • Certification
    Research Use Only
  • Estimated Purity
    99.28%
  • Molecular Formula
    C29H32ClF3N2O3
  • Molecular Weight
    549.02
  • Scientific Description
    Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.
  • SMILES
    CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O.Cl
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200