Alsterpaullone [237430-03-4]

Name: Alsterpaullone [237430-03-4]
SKU: AG-CR1-0036_A27
Price: 47 EUR
Availability: InStock

AG-CR1-0036

CAS Number237430-03-4

Product group Chemicals

Estimated Purity>98% (NMR)

Molecular Weight293.3

Overview

Supplier
AdipoGen Life Sciences
Product Name
Alsterpaullone [237430-03-4]
Delivery Days Customer
10
CAS Number
237430-03-4
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous,Warning
Molecular Formula
C16H11N3O3
Molecular Weight
293.3
Scientific Description
Chemical. CAS: 237430-03-4. Formula: C16H11N3O3. MW: 293.3. Potent CDK1/cyclin B (IC50 = 35 nM) inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E (IC50 = 200 nM), CDK5/p25 (IC50 = 40 nM), CDK5/p35 (IC50 = 40 nM). GSK-3beta (glycogen synthase kinase-3beta) inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor. - Potent CDK1/cyclin B (IC50 = 35 nM) inhibitor [1]. Anti-tumor compound [1] Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E (IC50 = 200 nM), CDK5/p25 (IC50 = 40 nM), CDK5/p35 (IC50 = 40 nM) [2, 4]. GSK-3beta (glycogen synthase kinase-3beta) inhibitor [2, 3]. Apoptosis inhibitor [6, 7]. Apoptosis inducer [5]. Angiogenesis inhibitor [8].
SMILES
[O-][N+](=O)C1=CC2=C(NC3=C2CC(=O)NC2=C3C=CC=C2)C=C1
Storage Instruction
2°C to 8°C
UNSPSC
12352200

Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity: C. Schultz, et al.; J. Med. Chem. 42, 2909 (1999)
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25: M. Leost, et al.; Eur. J. Biochem. 267, 5983 (2000)
Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor: M. Knockaert, et al.; J. Biol. Chem. 277, 25493 (2002)
The specificities of protein kinase inhibitors: an update: J. Bain, et al.; Biochem. J. 371, 199 (2003)
Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential: T. Lahusen, et al.; Mol Carcinog 36, 183 (2003)
Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells: T. Takadera, et al.; Neurosci. Lett. 408, 124
Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells: T. Takadera, et al.; Cell. Mol. Neurobiol. 30, 863 (2010)
Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro: S. Zahler, et al.; Angiogenesis 13, 239 (2010)