AMG-337 [1173699-31-4]
HY-18696
CAS Number1173699-31-4
Product group Chemicals
Estimated Purity99.19%
Molecular Weight463.46
Overview
- SupplierMedChem Express
- Product NameAMG-337 [1173699-31-4]
- Delivery Days Customer10
- CAS Number1173699-31-4
- CertificationResearch Use Only
- Estimated Purity99.19%
- Molecular FormulaC23H22FN7O3
- Molecular Weight463.46
- Scientific DescriptionAMG-337 is a potent, orally active, selective MET kinase inhibitor with IC50 values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis.
- SMILESO=C1C2=C(N=CC(OCCOC)=C2)C=CN1[C@@H](C3=NN=C4C(F)=CC(C5=CN(C)N=C5)=CN43)C
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200