AMG 487 [473719-41-4]

MedChem Express

AMG 487 [473719-41-4]

10

473719-41-4

Research Use Only

98.99%

C32H28F3N5O4

603.59

AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.

O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5

2°C to 8°C,-20°C,-80°C

12352200