AMI-1 [134-47-4, 160994-87-6]

Name: AMI-1 [134-47-4, 160994-87-6]
SKU: AG-CR1-0038_A27
Price: 319 EUR
Availability: InStock

AG-CR1-0038

Estimated Purity>99% (NMR)

Product group Chemicals

Molecular Weight592.4

Overview

Supplier
AdipoGen Life Sciences
Product Name
AMI-1 [134-47-4, 160994-87-6]
Delivery Days Customer
10
Certification
Research Use Only
Estimated Purity
>99% (NMR)
Hazard Information
Non-hazardous,Warning
Molecular Formula
C21H12N2O9S2Na4
Molecular Weight
592.4
Scientific Description
Chemical. CAS: 20324-87-2134-47-4 (free base). Formula: C21H12N2O9S2Na4. MW: 592.4. Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 microM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0 microM). - Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 microM) [1]. Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site [1]. Blocks peptide substrate binding [3]. HIV-1 RT polymerase inhibitor (IC50 = 5.0 microM) [2].
SMILES
[Na+].[Na+].[O-]C1=CC(=CC2=C1C=CC(NC(=O)NC1=CC3=C(C=C1)C([O-])=CC(=C3)S(=O)(=O)O[Na])=C2)S(=O)(=O)O[Na]
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004)
A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002)
Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach: Y. Feng, et al.; BBRC 379, 567 (2009)