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ProductsBack/Amlexanox [68302-57-8]
Chemical Structure
Chemical Structure
Chemical Structure

Amlexanox [68302-57-8]

Research Use Only
AG-CR1-3579
AdipoGen Life Sciences
CAS Number68302-57-8
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Product group Chemicals
Estimated Purity>98%
Molecular Weight298.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Amlexanox [68302-57-8]
  • Delivery Days Customer
    10
  • CAS Number
    68302-57-8
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C16H14N2O4
  • Molecular Weight
    298.3
  • Scientific Description
    Antiallergic [1,2]. Anti-inflammatory [2]. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release [3, 5]. Binds to HSP90. Inhibits C-terminal chaperone activity [4]. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner [6]. Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKepsilon. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake [7]. - Chemical. CAS: 68302-57-8. Formula: C16H14N2O4. MW: 298.3. Antiallergic. Anti-inflammatory. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release. Binds to HSP90. Inhibits C-terminal chaperone activity. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner. Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKepsilon. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake.
  • SMILES
    CC(C)C1=CC2=C(OC3=C(C=C(C(O)=O)C(N)=N3)C2=O)C=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Inhibition by amoxanox (AA-673) of the immunologically, leukotriene D4- or platelet-activating factor-stimulated bronchoconstriction in guinea pigs and rats: T. Saijo, et al.; Int. Arch. Allergy Appl. Immunol. 77, 315 (1985)
  • Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase: H. Makino, et al.; Int. Arch. Allergy Appl. Immunol. 82, 66 (1987)
  • Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro: M. Landriscina, et al.; J. Biol. Chem. 275, 32753 (2000)
  • Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox: M. Okada, et al.; Biochem. J. 374, 433 (2003)
  • Molecular level interactions of S100A13 with amlexanox: inhibitor for formation of the multiprotein complex in the nonclassical pathway of acidic fibroblast growth factor: S.G. Rani, et al.; Biochemistry 49, 2585 (2010)
  • Rescue of nonsense mutations by amlexanox in human cells: S. Gonzalez-Hilarion, et al.; Orphanet. J. Rare Dis. 7, 58 (2012)
  • An inhibitor of the protein kinases TBK1 and IKK-epsilon improves obesity-related metabolic dysfunctions in mice: S.M. Reilly, et al.; Nat. Med. 19, 313 (2013)