Antibiotic UK-1 [151271-53-3]

Catalog number: BVT-0013-C250
Brand: BioViotica
Packing: 250 ug
Other sizes: Other sizes available
Price: € 70.00
Expected delivery time: 7 days
Quantity:
Chemical Structure
Chemical Structure...

Product specifications for - Antibiotic UK-1 [151271-53-3]

Overview: 
Product group: Chemicals
Category: Antibiotics
CAS No.: 151271-53-3
Properties: 
Purity: >98%
Molecular Formula: C22H14N2O5
Molecular weight: 386.4
Datasheet: Datasheet
  Research Use Only
UNSPSC: 51280000
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: Antibiotic. Antifungal. Topoisomerase II (Topo II) inhibitor. Mg2+- and Zn2+-dependent DNA binding agent. Potent anticancer compound. - Chemical. CAS: 151271-53-3. Formula: C22H14N2O5. MW: 386.4. Isolated from Streptomyces sp. K17/9. Antibiotic. Antifungal. Topoisomerase II (Topo II) inhibitor. Mg2+- and Zn2+-dependent DNA binding agent. Potent anticancer compound.
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous, Warning
Additional information: 
Synonyms: BVT-0013-C250; BioViotica
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties: M. Ueki, et al.; J. Antibiot. 46, 1089 (1993) Read more
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II. Structural elucidation: K. Shibata, et al.; J. Antibiot. 46, 1095 (1993) Read more
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. III. Antibacterial action of demethyl UK-1: M. Ueki and M. Taniguchi; J. Antibiot. 50, 788 (1997) Read more
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. IV. Antifungal action of methyl UK-1: M. Ueki, et al.; J. Antibiot. 51, 883 (1998) Read more
The novel bis(benzoxazole) cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II: M.B. Reynolds, et al.; Bioorg. Chem. 27, 326 (1999) Read more
Evaluation of complexation of metal-mediated DNA-binding drugs to oligonucleotides via electrospray ionization mass spectrometry: M.L. Reyzer, et al.; Nucl. Acids Res. 29, E103 (2001) Read more
Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1: D. Kumar, et al.; Bioorg. Med. Chem. 10, 3997 (2002) Read more
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs: B.B. Wang, et al.; Bioorg. Med. Chem. Lett. 14, 3221 (2004) Read more
Synthesis and antimicrobial activity of some 5-[2-(morpholin-4-yl)acetamido] and/or 5-[2-(4-substituted piperazin-1-yl)acetamido]-2-(p-substituted phenyl)benzoxazoles: O. Temiz-Arpaci, et al.; Arch. Pharm. 338, 105 (2005) Read more
Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles: S.T. Huang, et al.; Bioorg. Med. Chem. 14, 6106 (2006) Read more