AP20187 [195514-80-8]

Catalog number: HY-13992_25mg
Brand: MedChem Express
Packing: 25 mg
Other sizes: 1 mg
5 mg
10 mg
10 mM
50 mg
Price: € 2195.00
Expected delivery time: 7 days

Product specifications for - AP20187 [195514-80-8]

Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 195514-80-8
Purity: >98%
Molecular Formula: C82H107N5O20
Molecular weight: 1482.749
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: AP20187 is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain. Target: small dimerizer drug Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine phosphorylation and activation of the insulin signaling pathway in both liver and muscle of AAV-treated NOD mice. AP20187 stimulation significantly increases hepatic glycogen content and muscular glucose uptake similarly to insulin [1]. The homodimerizer has been widely used to study signal transduction pathways (by inducing oligomerization of cell surface receptor proteins), but it can be used to induce the activity/re-localization of any protein that is affected by oligomerization. To test the role of homodimerization in kinase activation, we constructed a fusion protein consisting of the SLK catalytic domain (amino acids 1-373) and a modified FK506 binding protein, Fv (Fv-SLK 1-373). Addition of AP20187 (an analog of FK506) enhanced the homodimerization of Fv-SLK 1-373 [2].
Safety information: 
Additional information: 
Synonyms: HY-13992; AP 20187; AP-20187
The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia', Mary E. Haas. Circulation. 2016 Jul 5;134(1):61-72. Read more