Apitolisib [1032754-93-0]

MedChem Express

Apitolisib [1032754-93-0]

10

1032754-93-0

Research Use Only

97.88%

C23H30N8O3S

498.6

Apitolisib (GDC-0980; GNE 390; RG 7422) is a selective, potent, orally bioavailable Class I PI3 kinase and mTOR kinase (TORC1/2) inhibitor with IC50s of 5 nM/27 nM/7 nM/14 nM for PI3Kalpha/PI3Kbeta/PI3Kdelta/PI3Kgamma, and with a Ki of 17 nM for mTOR.

C[C@@H](C(N1CCN(CC1)CC2=C(C3=NC(C4=CN=C(N=C4)N)=NC(N5CCOCC5)=C3S2)C)=O)O

2°C to 8°C,-20°C,-80°C

12352200