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ProductsBack/Artesunate [88495-63-0]
Chemical Structure
Chemical Structure
Chemical Structure

Artesunate [88495-63-0]

Research Use Only
AG-CN2-0469
AdipoGen Life Sciences
CAS Number88495-63-0
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Product group Chemicals
Estimated Purity>98%
Molecular Weight384.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Artesunate [88495-63-0]
  • Delivery Days Customer
    10
  • CAS Number
    88495-63-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C19H28O8
  • Molecular Weight
    384.4
  • Scientific Description
    Chemical. CAS: 88495-63-0. Formula: C19H28O8. MW: 384.4. Semi-synthetic derivative of artemisinin originally isolated from Artemisia annua. Semi-synthetic derivative of artemisinin. Anti-malaria. Anti-schistosomiasis. Inhibitor of human cytomegalovirus (CMV). Apoptosis inducer. Anti-cancer. Immunosuppressant. Inhibits production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO). - Semi-synthetic derivative of artemisinin. Anti-malaria. Anti-schistosomiasis. Inhibitor of human cytomegalovirus (CMV). Apoptosis inducer. Anti-cancer. Immunosuppressant. Inhibits production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO). Functional ARX inhibitor. Enhancer of GABAA signalling. Targets Gephyrin. Inducer of glucose-6-phosphate dehydrogenase (G6PDH) activity (25fold), the rate limiting enzyme of the pentose phosphate pathway (PPP). Sown to have anti-SARS-CoV-2 activity with an EC50 of 12.98 +/- 5.30microM, and beeing potentially useful in the treatment of COVID-19.
  • SMILES
    [H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@]4(C)OO[C@@]13[C@]([H])(O[C@@H](OC(=O)CCC(O)=O)[C@@H]2C)O4
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • The antimalarial and toxic effect of artesunate on animal models: J. Tradit. Chin. Med. 2, 99 (1982)
  • Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis: R. Liu, et al.; Parasit. Vectors 4, 201 (2011)
  • Evaluation of the immunosuppressive activity of artesunate in vitro and in vivo: T. Li, et al.; Int. Immunopharmacol. 16, 306 (2013)
  • Inhibition of human cytomegalovirus replication by artemisinins: effects mediated through cell cycle modulation: S. Roy, et al.; Antimicrob. Agents Chemother. 59, 3870 (2015)
  • Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis: D.E. Jeong, et al.; Oncotarget 6, 33046 (2015)