Xevinapant (AT406) [1071992-99-8]
S2754
Product group Chemicals
Overview
- SupplierSelleck Chemicals
- Product NameXevinapant (AT406) [1071992-99-8]
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionXevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.
- UNSPSC12352200