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Luminespib (NVP-AUY922) [747412-49-3]

Research Use Only
S1069
Selleck Chemicals
Product group Chemicals
Price on request
Packing Size
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Overview

  • Supplier
    Selleck Chemicals
  • Product Name
    Luminespib (NVP-AUY922) [747412-49-3]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Scientific Description
    Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90alfa/bèta with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rbèta protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
  • UNSPSC
    12352200