Luminespib (NVP-AUY922) [747412-49-3]
S1069
Product group Chemicals
Overview
- SupplierSelleck Chemicals
- Product NameLuminespib (NVP-AUY922) [747412-49-3]
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionLuminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90alfa/bèta with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rbèta protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
- UNSPSC12352200