AV-412 free base [451492-95-8]

MedChem Express

AV-412 free base [451492-95-8]

10

451492-95-8

Research Use Only

98.33%

C27H28ClFN6O

507.0

AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

O=C(C=C)NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1C#CC(C)(C)N(CC4)CCN4C

2°C to 8°C,-20°C,-80°C

12352200