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AZ304 [942507-42-8]

HY-117273
MedChem Express
CAS Number942507-42-8
Product group Chemicals
Estimated Purity99.96%
Molecular Weight451.52
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    AZ304 [942507-42-8]
  • Delivery Days Customer
    10
  • CAS Number
    942507-42-8
  • Estimated Purity
    99.96%
  • Molecular Formula
    C27H25N5O2
  • Molecular Weight
    451.52
  • Scientific Description
    AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity.
  • SMILES
    O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200