AZD-2461 [1174043-16-3]

Catalog number: HY-13536_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: 5 mg
10 mM
10 mg
50 mg
Price: € 318.00
Expected delivery time: 10 days

Product specifications for - AZD-2461 [1174043-16-3]

Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 1174043-16-3
Purity: >98%
Molecular Formula: C22H22FN3O3
Molecular weight: 395.4268
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: AZD2461 is a novel PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by Pgp. IC50 Value: Target: PARP in vitro: in vivo: AZD2461 has an 80-fold increased Mdr1b expression on Olaparib-resistant KB1P tumor T6-28, without inhibition of Pgp. AZD2461 induces loss of 53BP1 expression in mice with KB1P tumors with short-term treatment. Long-term AZD2461 treatment is well tolerated and doubled the median relapse-free survival. Clinical trial: An Open-Label, Dose-Escalation Study of AZD-2461 .Phase 1 cpmpleted
Safety information: 
Additional information: 
Synonyms: HY-13536; AZD2461; AZD 2461
Drug Driven Synthetic Lethality: bypassing tumor cell genetics with a combination of Dbait and PARPinhibitors.', Jdey W. Clin Cancer Res. 2017 Feb 15;23(4):1001-1011. Read more