Osimertinib mesylate [1421373-66-1]

MedChem Express

Osimertinib mesylate [1421373-66-1]

10

1421373-66-1

Research Use Only

98.74%

C29H37N7O5S

595.71

Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O.CS(=O)(O)=O

2°C to 8°C,-20°C,-80°C

12352200