AZD-5153 6-hydroxy-2-naphthoic acid [1869912-40-2]
S8344
Overview
- SupplierSelleck Chemicals
- Product NameAZD-5153 6-hydroxy-2-naphthoic acid [1869912-40-2]
- Delivery Days Customer9
- CAS Number1869912-40-2
- CertificationResearch Use Only
- Scientific DescriptionAZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.
- UNSPSC12352200