AZD8055, Free Base [1009298-09-2]
ORB153601
CAS Number1009298-09-2
Product group Chemicals
Estimated Purity>99%
Molecular Weight465.54 g/mol
Overview
- SupplierBiorbyt
- Product NameAZD8055, Free Base [1009298-09-2]
- Delivery Days Customer16
- CAS Number1009298-09-2
- CertificationResearch Use Only
- Estimated Purity>99%
- Molecular FormulaC25H31N5O 4
- Molecular Weight465.54 g/mol
- Scientific DescriptionAZD8055 is also named as[CCG-168]. AZD8055 is a novel ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR) kinase with an IC50 value of 0. 8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1, mTORC2 substrate AKT, and downstream proteins. AZD8055 also blocked the chemotherapy-induced cell death promoted by ectopic wild-type p62. AZD8055 potently inhibits proliferation, induces autophagy and apoptosis in different cells. Up to 10 microM AZD8055 showed no significant activity against a panel of 260 kinases at concentrations.
- Storage Instruction-20°C or -80°C
- UNSPSC12352200