Azoramide [932986-18-0]

MedChem Express

Azoramide [932986-18-0]

10

932986-18-0

Research Use Only

C15H17ClN2OS

308.83

Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity.

CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O

2°C to 8°C,-20°C,-80°C

12352200