Bafilomycin A1 [88899-55-2]

MedChem Express

Bafilomycin A1 [88899-55-2]

10

88899-55-2

Research Use Only

95%

C35H58O9

622.83

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.

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-20°C,-80°C

12352200