BAY 43-9006 [284461-73-0]

Name: BAY 43-9006 [284461-73-0]
SKU: AG-CR1-0025_A27
Price: 21 EUR
Availability: BackOrder

AG-CR1-0025

CAS Number284461-73-0

Product group Chemicals

Estimated Purity>98% (NMR)

Molecular Weight464.8

Overview

Supplier
AdipoGen Life Sciences
Product Name
BAY 43-9006 [284461-73-0]
Delivery Days Customer
10
CAS Number
284461-73-0
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous,Warning
Molecular Formula
C21H16ClF3N4O3
Molecular Weight
464.8
Scientific Description
Antitumor compound [1]. Broad-spectrum kinase inhibitor [2]. Raf kinase inhibitor [2, 3]. Apoptosis inducer [3, 4]. Cytostatic [5]. Angiogenesis inhibitor [2, 5]. Review [6]. - Chemical. CAS: 284461-73-0. Formula: C21H16ClF3N4O3. MW: 464.8. Antitumor compound. Broad-spectrum kinase inhibitor. Raf kinase inhibitor. Apoptosis inducer. Cytostatic. Angiogenesis inhibitor. Review.
SMILES
CNC(=O)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)=C1
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

BAY 43-9006: preclinical data: S. Wilhelm & D.S. Chien; Curr. Pharm. Des. 8, 2255 (2002)
Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature: L. Adnane, et al.; Meth. Enzymol. 407, 597 (2005)
The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells: D.J. Panka, et al.; Cancer Res. 66, 1611 (2006)
The kinase inhibitor Sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress: M. Rahmani, et al.; Mol. Cell. Biol. 27, 5499 (2007)
BAY-43-9006 Bayer/Onyx: J.T. Lee & J.A. McCubrey; Curr. Opin. Investig. Drugs 4, 757 (2003)
Sorafenib (BAY 43-9006): review of clinical development: R. Ng & E.X. Chen; Curr. Clin. Pharmacol. 1, 223 (2006)