BAY 61-3606 dihydrochloride [648903-57-5]
HY-14985
CAS Number648903-57-5
Product group Chemicals
Estimated Purity98.18%
Molecular Weight463.32
Overview
- SupplierMedChem Express
- Product NameBAY 61-3606 dihydrochloride [648903-57-5]
- Delivery Days Customer10
- CAS Number648903-57-5
- CertificationResearch Use Only
- Estimated Purity98.18%
- Molecular FormulaC20H20Cl2N6O3
- Molecular Weight463.32
- Scientific DescriptionBAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
- SMILESO=C(N)C1=CC=CN=C1NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC4=NC=CN24.[H]Cl.[H]Cl
- Storage Instruction-20°C,-80°C
- UNSPSC12352200