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BAY 61-3606 dihydrochloride [648903-57-5]

Research Use Only
HY-14985
MedChem Express
CAS Number648903-57-5
Product group Chemicals
Estimated Purity98.18%
Molecular Weight463.32
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    BAY 61-3606 dihydrochloride [648903-57-5]
  • Delivery Days Customer
    10
  • CAS Number
    648903-57-5
  • Certification
    Research Use Only
  • Estimated Purity
    98.18%
  • Molecular Formula
    C20H20Cl2N6O3
  • Molecular Weight
    463.32
  • Scientific Description
    BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
  • SMILES
    O=C(N)C1=CC=CN=C1NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC4=NC=CN24.[H]Cl.[H]Cl
  • Storage Instruction
    -20°C,-80°C
  • UNSPSC
    12352200