Belnacasan [273404-37-8]

MedChem Express

Belnacasan [273404-37-8]

10

273404-37-8

Research Use Only

98.03%

C24H33ClN4O6

509.0

Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1beta and IL-18 by human PBMCs with an IC50 of ~0.7 microM.

ClC1=C(N)C=CC(C(N[C@@H](C(C)(C)C)C(N2[C@H](C(N[C@H]3CC(O[C@H]3OCC)=O)=O)CCC2)=O)=O)=C1

2°C to 8°C,-20°C,-80°C

12352200