Benzamil hydrochloride [161804-20-2]

MedChem Express

Benzamil hydrochloride [161804-20-2]

10

161804-20-2

99.6%

C13H15Cl2N7O

356.21

Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 microM.

O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCC2=CC=CC=C2)=N.[H]Cl

2°C to 8°C,-20°C,-80°C

12352200