I-BET282 [1422554-34-4]

MedChem Express

I-BET282 [1422554-34-4]

10

1422554-34-4

Research Use Only

99.12%

C25H30N4O4

450.53

I-BET282 is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282 shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD).

COC1=C(C2=C(C)ON=C2C)C=C(N=CC3=C4N(C(C5CCOCC5)=N3)[C@@H](COC)C)C4=C1

2°C to 8°C,-20°C,-80°C

12352200