Dactolisib [915019-65-7]

MedChem Express

Dactolisib [915019-65-7]

10

915019-65-7

96.41%

C30H23N5O

469.54

Dactolisib (BEZ235) is an orally active and dual pan-class I PI3K and mTOR kinase inhibitor with IC50s of 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110alpha/p110gamma/p110delta/p110beta and mTOR, respectively. Dactolisib (BEZ235) inhibits both mTORC1 and mTORC2.

CN(C1=C2C3=CC(C4=CC5=CC=CC=C5N=C4)=CC=C3N=C1)C(N2C6=CC=C(C=C6)C(C)(C#N)C)=O

2°C to 8°C,-20°C,-80°C

12352200