BIBS 39 [133085-33-3]

Catalog number: HY-19732_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: 5 mg
10 mM
25 mg
50 mg
Price: € 185.00
Expected delivery time: 10 days

Product specifications for - BIBS 39 [133085-33-3]

Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 133085-33-3
Purity: >98%
Molecular Formula: C32H36N4O3
Molecular weight: 524.6533
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. Target: Angiotensin Receptor in vitro: BIBS 39 displaces [125I] AII from its specific binding sites with a Ki value of 29 +/- 7 nM for the AII subtype 1 (AT1) receptor and a Ki value of 480 +/- 110 nM for the AII subtype 2 (AT2) receptor. BIBS 222 shows a Ki value of 20 +/- 7 nM for the AT1 subtype and a Ki value of 730 +/- 170 nM for the AT2 subtype. BIBS 39 is 17 times more selective for the AT1 subtype and BIBS 222 37 times. BIBS 39 shifts the AII concentration-contractile response curves in isolated rabbit aorta to the right in a parallel fashion. [1] in vivo: In pithed rats, BIBS 39 dependently shifts the dose-response curve of AII to the right without affecting the maximal response. BIBS 222 also causes parallel shifts to the right but a significant reduction of the maximal responses was observed at 3 and 10 mg/kg i.v. These results show that the benzimidazole derivatives BIBS 39 is a potent and selective AII receptor antagonists. Substitution with a benzimidazole moiety results into a considerable loss of selectivity for the AT1 receptor subtype compared with an imidazole moiety as, for instance, in DuP 753.[1] BIBS 39 is a new nonpeptide angiotensin receptor blockers that has affinity for both AT1- and AT2-receptors, is also a potent antagonist of the cardiovascular effects of AII in pithed rabbits. [2]
Safety information: 
Additional information: 
Synonyms: HY-19732; BIBS39; BIBS-39