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ProductsBack/Bisindolylmaleimide III [137592-43-9]
Chemical Structure
Chemical Structure
Chemical Structure

Bisindolylmaleimide III [137592-43-9]

Research Use Only
AG-CR1-0112
AdipoGen Life Sciences
Estimated Purity>98% (NMR)
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Product group Chemicals
Molecular Weight384.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Bisindolylmaleimide III [137592-43-9]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (NMR)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C23H20N4O2
  • Molecular Weight
    384.4
  • Scientific Description
    Chemical. CAS: 137592-43-9. Formula: C23H20N4O2. MW: 384.4. Potent and selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). - Potent and selective protein kinase C (PKC) inhibitor [1-3]. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2) [4, 5].
  • SMILES
    NCCCN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CNC2=C1C=CC=C2
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C: D. Toullec, et al.; J. Biol. Chem. 266, 15771 (1991)
  • Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides: P.D. Davis, et al.; J. Med. Chem. 35, 177 (1992)
  • Protein kinase C inhibitors; structure-activity relationships in K252c- related compounds: S. Fabre & M. Prudhomme; Bioorg. Med. Chem. 1, 193 (1993)
  • Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)
  • An immuno-chemo-proteomics method for drug target deconvolution: C. Saxena, et al.; J. Proteome Res. 7, 3490 (2008)