Bisindolylmaleimide VIII . acetate [138516-31-1]

Name: Bisindolylmaleimide VIII . acetate [138516-31-1]
SKU: AG-CR1-0114_A27
Price: 57 EUR
Availability: InStock

AG-CR1-0114

Estimated Purity>98% (NMR)

Product group Chemicals

Molecular Weight398.5 . 60.1

Overview

Supplier
AdipoGen Life Sciences
Product Name
Bisindolylmaleimide VIII . acetate [138516-31-1]
Delivery Days Customer
10
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous
Molecular Formula
C24H22N4O2 . CH3COOH
Molecular Weight
398.5 . 60.1
Scientific Description
Chemical. CAS: 138516-31-1. Formula: C24H22N4O2 . CH3COOH. MW: 398.5 . 60.1. Selective protein kinase C (PKC) inhibitor. Inhibits proliferation of cultured mouse epidermal keratinocytes. Enhances Fas- and TRAIL-mediated apoptosis. Inhibits T cell-mediated autoimmune diseases. Inhibits stimulation of insulin secretion by glucose. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). - Selective protein kinase C (PKC) inhibitor [1-3]. Inhibits proliferation of cultured mouse epidermal keratinocytes [4]. Enhances Fas- and TRAIL-mediated apoptosis [5, 6]. Inhibits T cell-mediated autoimmune diseases [5]. Inhibits stimulation of insulin secretion by glucose [8]. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2) [7].
SMILES
CC(O)=O.CN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CN(CCCN)C2=C1C=CC=C2
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages: P. Dieter & E. Fitzke; BBRC 181, 396 (1991)
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction: R.A. Bit, et al.; J. Med. Chem. 36, 21 (1993)
Effects of the selective protein kinase C inhibitor, Ro 31-7549, on the proliferation of cultured mouse epidermal keratinocytes: W.B. Bollag, et al.; J. Invest. Dermatol. 100, 240 (1993)
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases: T. Zhou, et al.; Nat. Med. 5, 42 (1999)
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways: T. Ohtsuka & T. Zhou; J. Biol. Chem. 277, 29294 (2002)
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)
Different signaling pathways involved in glucose- and cell swelling-induced insulin secretion by rat pancreatic islets in vitro: Z. Bacova, et al.; Cell Physiol. Biochem. 16, 59 (2005)