Bisindolylmaleimide X . hydrochloride [131848-97-0, 145317-11-9]

Name: Bisindolylmaleimide X . hydrochloride [131848-97-0, 145317-11-9]
SKU: AG-CR1-0113_A27
Price: 84 EUR
Availability: InStock

AG-CR1-0113

Estimated Purity>98% (NMR)

Product group Chemicals

Molecular Weight424.5 . 36.5

Overview

Supplier
AdipoGen Life Sciences
Product Name
Bisindolylmaleimide X . hydrochloride [131848-97-0, 145317-11-9]
Delivery Days Customer
10
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous
Molecular Formula
C26H24N4O2 . HCl
Molecular Weight
424.5 . 36.5
Scientific Description
Chemical. CAS: 145317-11-9131848-97-0 (free base). Formula: C26H24N4O2 . HCl. MW: 424.5 . 36.5. Selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Inhibits superoxide generation in human neutrophils. - Selective protein kinase C (PKC) inhibitor [1-3]. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2) [3]. Inhibits superoxide generation in human neutrophils [1].
SMILES
CC(C)(C=C)C12CC3N(C1NC1=C2C=CC=C1)C(=O)C1CC2(C(NC4=C2C=CC=C4)N1C3=O)C(C)(C)C=C
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli: R.E. Muid, et al.; FEBS Lett. 293, 169 (1991)
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)