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BMS-599626 Hydrochloride [873837-23-1]

Research Use Only
HY-12010
MedChem Express
CAS Number873837-23-1
Product group Chemicals
Estimated Purity99.87%
Molecular Weight567.01
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    BMS-599626 Hydrochloride [873837-23-1]
  • Delivery Days Customer
    10
  • CAS Number
    873837-23-1
  • Certification
    Research Use Only
  • Estimated Purity
    99.87%
  • Molecular Formula
    C27H28ClFN8O3
  • Molecular Weight
    567.01
  • Scientific Description
    BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.
  • SMILES
    O=C(OC[C@H]1NCCOC1)NC2=CN(C3=C2C)N=CN=C3NC4=CC5=C(C=C4)N(CC6=CC(F)=CC=C6)N=C5.Cl
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200