BMS-599626 Hydrochloride [873837-23-1]
HY-12010
CAS Number873837-23-1
Product group Chemicals
Estimated Purity99.87%
Molecular Weight567.01
Overview
- SupplierMedChem Express
- Product NameBMS-599626 Hydrochloride [873837-23-1]
- Delivery Days Customer10
- CAS Number873837-23-1
- CertificationResearch Use Only
- Estimated Purity99.87%
- Molecular FormulaC27H28ClFN8O3
- Molecular Weight567.01
- Scientific DescriptionBMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.
- SMILESO=C(OC[C@H]1NCCOC1)NC2=CN(C3=C2C)N=CN=C3NC4=CC5=C(C=C4)N(CC6=CC(F)=CC=C6)N=C5.Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200