Avagacestat [1146699-66-2]

MedChem Express

Avagacestat [1146699-66-2]

10

1146699-66-2

Research Use Only

95%

C20H17ClF4N4O4S

520.89

Avagacestat (BMS-708163) is a potent inhibitor of gamma-secretase, with IC50s of 0.27 nM and 0.30 nM for Abeta42 and Abeta40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 microM. Avagacestat can be used for Alzheimer disease research.

O=S(N([C@@H](C(N)=O)CCC(F)(F)F)CC1=CC=C(C2=NOC=N2)C=C1F)(C3=CC=C(Cl)C=C3)=O

2°C to 8°C,-20°C,-80°C

12352200