Bosutinib (SKI-606) [380843-75-4]
S1014
Overview
- SupplierSelleck Chemicals
- Product NameBosutinib (SKI-606) [380843-75-4]
- Delivery Days Customer9
- CAS Number380843-75-4
- CertificationResearch Use Only
- Scientific DescriptionBosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
- UNSPSC12352200