BRD4 degrader AT1 [2098836-45-2]

MedChem Express

BRD4 degrader AT1 [2098836-45-2]

10

2098836-45-2

Research Use Only

98.69%

C48H58ClN9O5S3

972.68

BRD4 degrader AT1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 as a highly selective Brd4 degrader, with a Kd of 44 nM for Brd4BD2 in cells.

CC1=C(C)SC2=C1C(C3=CC=C(Cl)C=C3)=N[C@@H](CC(NCCCCCCSC(C)(C)[C@H](NC(C)=O)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)C7=NN=C(C)N27

-20°C,-80°C

12352200