Butein [487-52-5]

MedChem Express

Butein [487-52-5]

10

487-52-5

98.01%

C15H12O5

272.25

Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 microM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 microM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC).

OC1=CC=C(C(/C=C/C2=CC(O)=C(O)C=C2)=O)C(O)=C1

2°C to 8°C,-20°C,-80°C

12352200