Cabozantinib (BMS-907351) [849217-68-1]
S1119
Product group Chemicals
Overview
- SupplierSelleck Chemicals
- Product NameCabozantinib (BMS-907351) [849217-68-1]
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionCabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3bèta/NF-kappaB signaling pathway.
- UNSPSC12352200