Celastrol (NSC 70931) [34157-83-0]

Selleck Chemicals

Celastrol (NSC 70931) [34157-83-0]

9

34157-83-0

Research Use Only

Celastrol (NSC 70931, Tripterine) is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 muM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.

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