Alectinib [1256580-46-7]

MedChem Express

Alectinib [1256580-46-7]

10

1256580-46-7

Research Use Only

95.8%

C30H34N4O2

482.62

Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration.

N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1

2°C to 8°C,-20°C,-80°C

12352200