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ProductsBack/Chloroguanabenz . acetate [23113-55-5]
Chemical Structure
Chemical Structure
Chemical Structure

Chloroguanabenz . acetate [23113-55-5]

Research Use Only
AG-MR-C0036
AdipoGen Life Sciences
Estimated Purity>95% (NMR)
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Product group Chemicals
Molecular Weight265.5 . 60.1
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Chloroguanabenz . acetate [23113-55-5]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • Certification
    Research Use Only
  • Estimated Purity
    >95% (NMR)
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C8H7Cl3N4 . C2H4O2
  • Molecular Weight
    265.5 . 60.1
  • Scientific Description
    Antiprion agent. Inhibitor of protein aggregation. Specifically reduces accumulation of a pathogenic fragment of Huntingtin in a transiently transfected cellular model of Huntingtons disease (HD). Tool for treating HD and other polyglutamine expansion associated diseases. - Chemical. CAS: 23113-55-5. Formula: C8H7Cl3N4 . C2H4O2. MW: 265.5 . 60.1. Antiprion agent. Inhibitor of protein aggregation. Specifically reduces accumulation of a pathogenic fragment of Huntingtin in a transiently transfected cellular model of Huntingtons disease (HD). Tool for treating HD and other polyglutamine expansion associated diseases.
  • SMILES
    CC(=N)N\N=C\C1=C(Cl)C=CC(Cl)=C1Cl
  • Storage Instruction
    2°C to 8°C,-20°C
  • UN Number
    UN 2811
  • UNSPSC
    12352200

References

  • Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions: D. Tribouillard-Tanvier, et al.; PLoS One 3, e1981 (2008)
  • Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases: A. Bertolotti & M. Blondel; Patent WO002008041133A2 (2008)
  • Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography: F. Gug, et al.; Bioconjug. Chem. 21, 279 (2010)