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ProductsBack/Ciglitazone [74772-77-3]
Chemical Structure
Chemical Structure
Chemical Structure

Ciglitazone [74772-77-3]

Research Use Only
AG-CR1-0033
AdipoGen Life Sciences
CAS Number74772-77-3
DownloadDatasheet
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Product group Chemicals
Estimated Purity>99% (NMR)
Molecular Weight333.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Ciglitazone [74772-77-3]
  • Delivery Days Customer
    10
  • CAS Number
    74772-77-3
  • Certification
    Research Use Only
  • Estimated Purity
    >99% (NMR)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C18H23NO3S
  • Molecular Weight
    333.5
  • Scientific Description
    Chemical. CAS: 74772-77-3. Formula: C18H23NO3S. MW: 333.5. Selective PPARgamma agonist (EC50=3 microM). Hypoglycemic agent. Angiogenesis inhibitor. Anti-inflammatory. Apoptosis inducer. - Selective PPARgamma agonist (EC50=3 microM) [1]. Hypoglycemic agent [2, 3]. Angiogenesis inhibitor [4]. Anti-inflammatory [5]. Apoptosis inducer [6].
  • SMILES
    CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996)
  • Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent: T. Fujita, et al.; Diabetes 32, 804 (1983)
  • [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994)
  • Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999)
  • The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice: M.E. Stegenga, et al.; Crit. Care Med. 37, 614 (2009)
  • Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock: R.S. Chima, et al.; Int. J. Clin. Exp. Med. 3, 1 (2010)