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Cilengitide [188968-51-6]

Research Use Only
HY-16141
MedChem Express
CAS Number188968-51-6
Product group Chemicals
Estimated Purity95.18%
Molecular Weight588.66
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Cilengitide [188968-51-6]
  • Delivery Days Customer
    10
  • CAS Number
    188968-51-6
  • Certification
    Research Use Only
  • Estimated Purity
    95.18%
  • Molecular Formula
    C27H40N8O7
  • Molecular Weight
    588.66
  • Scientific Description
    Cilengitide (EMD 121974) is a potent integrins antagonist with IC50s of 0.61 nM (alphanubeta3), 8.4 nM (alphanubeta5) and 14.9 nM (alpha5beta1), respectively. Cilengitide inhibits the binding of alphanubeta3 and alphanubeta5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-beta/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers.
  • SMILES
    O=C(NCC(N[C@H](C(N[C@H](CC1=CC=CC=C1)C(N([C@H]2C(C)C)C)=O)=O)CC(O)=O)=O)[C@H](CCCNC(N)=N)NC2=O
  • Storage Instruction
    -20°C,-80°C
  • UNSPSC
    12352200