Cilengitide [188968-51-6]
HY-16141
CAS Number188968-51-6
Product group Chemicals
Estimated Purity95.18%
Molecular Weight588.66
Overview
- SupplierMedChem Express
- Product NameCilengitide [188968-51-6]
- Delivery Days Customer10
- CAS Number188968-51-6
- CertificationResearch Use Only
- Estimated Purity95.18%
- Molecular FormulaC27H40N8O7
- Molecular Weight588.66
- Scientific DescriptionCilengitide (EMD 121974) is a potent integrins antagonist with IC50s of 0.61 nM (alphanubeta3), 8.4 nM (alphanubeta5) and 14.9 nM (alpha5beta1), respectively. Cilengitide inhibits the binding of alphanubeta3 and alphanubeta5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-beta/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers.
- SMILESO=C(NCC(N[C@H](C(N[C@H](CC1=CC=CC=C1)C(N([C@H]2C(C)C)C)=O)=O)CC(O)=O)=O)[C@H](CCCNC(N)=N)NC2=O
- Storage Instruction-20°C,-80°C
- UNSPSC12352200