Colcemid [477-30-5]

Catalog number: AG-CR1-3567-M001
Brand: AdipoGen Life Sciences
Packing: 1 mg
Other sizes: 5 mg
Price: € 35.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - Colcemid [477-30-5]

Product group: Chemicals
Category: Other
Source: Semisynthetic from colchicine (Prod. No. AG-CN2-0048).
CAS No.: 477-30-5
Purity: >98% (HPLC)
Molecular Formula: C21H25NO5
Molecular weight: 371.4
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer. Thrombopoietic agent.
Safety information: 
ADR klasse: 6; 1
UN Number: UN2811
Hazard information: H301
Additional information: 
Synonyms: AG-CR1-3567-M001; AdipoGen Life Sciences; Demecolcine; BRN 2822892
Effect of colcemid on fibroblast motility: M.H. Gail & C.W. Boone; Exp. Cell Res. 65, 221 (1971) Read more
Mitosis in human leukemic leukocytes during colcemid inhibition and recovery: M. McGill & B. R. Brinkley; Cancer Res. 32, 746 (1972) Read more
The effects of colcemid on hematopoiesis in the mouse: P.A. Bunn Jr. et al.; J. Clin. Invest. 58, 1280 (1976) Read more
Colcemid and colchicine binding to tubulin. Similarity and dissimilarity: A.C. Banerjee & B. Bhattacharyya; FEBS Lett. 99, 333 (1979) Read more
Comparison of mitostatic effect, cell uptake and tubulin-binding activity on colchicine and colcemid: A.S. Serpinskaya, et al.; Biochim. Biophys. Acta 673, 86 (1981) Read more
Action of demecolcine (colcemid) in the murine sarcoma 180 tumor: T. Nomura & J.E. Plager; Cancer Treat. Rep. 65, 283 (1981) Read more
Colcemid effects on B16 melanoma cell progression and aberrant mitotic division: B.K. Bhuyan, et al.; J. Cell Physiol. 132, 237 (1987) Read more
Colcemid and the mitotic cycle: C.L. Rieder & R.E. Palazzo; J. Cell. Sci. 102, 387 (1992) Read more
Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells: S.W. Sherwood, et al.; Exp. Cell. Res. 215, 373 (1994) Read more
Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo) 35, 41 (1994) Read more