Columbin [546-97-4]

MedChem Express

Columbin [546-97-4]

10

546-97-4

99.77%

C20H22O6

358.39

Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 microM) over COX-1 (EC50=327 microM).

O=C1[C@](C=C2)(O)[C@@](CC3)(C)[C@@]([C@@](C[C@@H](C4=COC=C4)O5)(C)[C@]3([H])C5=O)([H])[C@]2([H])O1

2°C to 8°C,-20°C,-80°C

12352200