Compound E [209986-17-4]

MedChem Express

Compound E [209986-17-4]

10

209986-17-4

98.75%

C27H24F2N4O3

490.5

Compound E is a gamma-secretase inhibitor. Compound E bloks beta-amyloid(40), beta-amyloid(42), and Notch gamma-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

FC1=CC(CC(N[C@@H](C)C(N[C@@H]2C(N(C)C(C=CC=C3)=C3C(C4=CC=CC=C4)=N2)=O)=O)=O)=CC(F)=C1

-20°C,-80°C

12352200