Cot inhibitor-1 [915365-57-0]

MedChem Express

Cot inhibitor-1 [915365-57-0]

10

915365-57-0

Research Use Only

95.03%

C27H27Cl2FN8

553.46

Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM.

N#CC1=C(C2=CC(NCC3=CN(CCN4CCCCCC4)N=N3)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5

2°C to 8°C,-20°C,-80°C

12352200