CP-724714 [383432-38-0]

MedChem Express

CP-724714 [383432-38-0]

9

383432-38-0

Research Use Only

98%

C27H27N5O3

469.53

CP-724714 is a potent, selective and orally active ErbB2 (HER2) tyrosine kinase inhibitor, with an IC50 of 10 nM. CP-724714 displays a marked selectivity against EGFR kinase (IC50=6400 nM). CP-724714 potently inhibits ErbB2 receptor autophosphorylation in intact cells. Antitumor activities.

O=C(COC)NC/C=C/C1=CC2=C(N=CN=C2C=C1)NC3=CC=C(C(C)=C3)OC4=CC=C(N=C4)C.[(E)]

2°C to 8°C,-20°C,-80°C

12352200