Crizotinib hydrochloride [1415560-69-8]
HY-50878A
CAS Number1415560-69-8
Product group Chemicals
Estimated Purity99.13%
Molecular Weight486.8
Overview
- SupplierMedChem Express
- Product NameCrizotinib hydrochloride [1415560-69-8]
- Delivery Days Customer10
- CAS Number1415560-69-8
- CertificationResearch Use Only
- Estimated Purity99.13%
- Molecular FormulaC21H23Cl3FN5O
- Molecular Weight486.8
- Scientific DescriptionCrizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition.
- SMILESClC1=C(F)C=CC(Cl)=C1[C@H](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C.[H]Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200