Crizotinib (PF-02341066) [877399-52-5]

Selleck Chemicals

Crizotinib (PF-02341066) [877399-52-5]

9

Research Use Only

Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.

12352200