CX-5461 dihydrochloride
HY-13323A
Overview
- SupplierMedChem Express
- Product NameCX-5461 dihydrochloride
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity98.07%
- Molecular FormulaC27H29Cl2N7O2S
- Molecular Weight586.54
- Scientific DescriptionCX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 microM).
- SMILES[H]Cl.CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1.[H]Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200